1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.00000 0.00000 0.00000 2004-08-31 2004-06-03 1TJA 0 1 1 M SINGLE WAVELENGTH 1.0 Situs v.2.0 REAL Laplacian filtered real space Situs v.2.0 Back projection 4.10442 3.93285 16 CTF correction of each particle Catalase crystals diffraction The deposited structures are components of the T4 tail baseplate in the so-called "star" conformation. In order to assemble a biological multimer (the sixfold symmetric baseplate) out of the deposited structures, one needs to multiply them via a sixfold along Z axis. The baseplate in the star conformation contains at least six other proteins, for which the authors do not have atomic structures yet. Thus, when you multiply the deposited crystal structures, you will have a lot of empty space between them. SINGLE PARTICLE bacteriophage T4 Phage treated with 3 M urea to contract tails H2O gene product 8 dimer gene product 9 trimer gene product 11 trimer 1 1 1 2002-01-06 100 FEI/PHILIPS CM300FEG/T 500 3400 0 0 1.4 BRIGHT FIELD 20 SPOT SCAN 45000 47000 FIELD EMISSION GUN 300 20 7.5 BACTERIA(EUBACTERIA) Escherichia coli Escherichia coli VIRION STRAIN 02.043.0.01.005 CRYO-ELECTRON MICROSCOPY REL N Y 2004-06-03 N N SR Y 2004-07-05 2004-06-03 2004-06-03 HPUB Y HOLD FOR PUBLICATION HOLD FOR PUBLICATION RELEASE NOW RCSB RCSB explicit Crystal structure of gp8 Crystal structure of gp9 Crystal structure of gp11 Fitting Of Gp8 Structure Into The Cryo-em Reconstruction Of The Bacteriophage T4 Baseplate Fitting Of Gp9 Structure Into The Cryo-em Reconstruction Of The Bacteriophage T4 Baseplate Fitting Of Gp11 Structure Into The Cryo-em Reconstruction Of The Bacteriophage T4 Baseplate MNDSSVIYRAIVTSKFRTEKMLNFYNSIGSGPDKNTIFITFGRSEPWSSNENEVGFAPPYPTDSVLGVTDMWTHMMGTVK VLPSMLDAVIPRRDWGDTRYPDPYTFRINDIVVCNSAPYNATESGAGWLVYRCLDVPDTGMCSIASLTDKDECLKLGGKW TPSARSMTPPEGRGDAEGTIEPGDGYVWEYLFEIPPDVSINRCTNEYIVVPWPEELKEDPTRWGYEDNLTWQQDDFGLIY RVKANTIRFKAYLDSVYFPEAALPGNKGFRQISIITNPLEAKAHPNDPNVKAEKDYYDPEDLMRHSGEMIYMENRPPIIM AMDQTEEINILFTF MFIQEPKKLIDTGEIGNASTGDILFDGGNKINSDFNAIYNAFGDQRKMAVANGTGADGQIIHATGYYQKHSITEYATPVK VGTRHDIDTSTVGVKVIIERGELGDCVEFINSNGSISVTNPLTIQAIDSIKGVSGNLVVTSPYSKVTLRCISSDNSTSVW NYSIESMFGQKESPAEGTWNISTSGSVDIPLFHRTEYNMAKLLVTCQSVDGRKIKTAEINILVDTVNSEVISSEYAVMRV GNETEEDEIANIAFSIKENYVTATISSSTVGMRAAVKVIATQKIGVAQ MSLLNNKAGVISRLADFLGFRPKTGDIDVMNRQSVGSVTISQLAKGFYEPNIESAINDVHNFSIKDVGTIITNKTGVSPE GVSQTDYWAFSGTVTDDSLPPGSPITVLVFGLPVSATTGMTAIEFVAKVRVALQEAIASFTAINSYKDHPTDGSKLEVTY LDNQKHVLSTYSTYGITISQEIISESKPGYGTWNLLGAQTVTLDNQQTPTVFYHFERTA VIRUS/VIRAL PROTEIN fitting, docking, cryo-EM, gp8, gp9, gp11 SWS VG08_BPT4 P19062 1 MNDSSVIYRAIVTSKFRTEKMLNFYNSIGSGPDKNTIFITFGRSEPWSSNENEVGFAPPYPTDSVLGVTDMWTHMMGTVKVLPSMLDAVIPRRDWGDTRYPDPYTFRINDIVVCNSAPYNATESGAGWLVYRCLDVPDTGMCSIASLTDKDECLKLGGKWTPSARSMTPPEGRGDAEGTIEPGDGYVWEYLFEIPPDVSINRCTNEYIVVPWPEELKEDPTRWGYEDNLTWQQDDFGLIYRVKANTIRFKAYLDSVYFPEAALPGNKGFRQISIITNPLEAKAHPNDPNVKAEKDYYDPEDLMRHSGEMIYMENRPPIIMAMDQTEEINILFTF 1 SWS VG09_BPT4 P10927 1 MFIQEPKKLIDTGEIGNASTGDILFDGGNKINSDFNAIYNAFGDQRKMAVANGTGADGQIIHATGYYQKHSITEYATPVKVGTRHDIDTSTVGVKVIIERGELGDCVEFINSNGSISVTNPLTIQAIDSIKGVSGNLVVTSPYSKVTLRCISSDNSTSVWNYSIESMFGQKESPAEGTWNISTSGSVDIPLFHRTEYNMAKLLVTCQSVDGRKIKTAEINILVDTVNSEVISSEYAVMRVGNETEEDEIANIAFSIKENYVTATISSSTVGMRAAVKVIATQKIGVAQ 1 SWS VG11_BPT4 P10929 2 MSLLNNKAGVISRLADFLGFRPKTGDIDVMNRQSVGSVTISQLAKGFYEPNIESAINDVHNFSIKDVGTIITNKTGVSPEGVSQTDYWAFSGTVTDDSLPPGSPITVLVFGLPVSATTGMTAIEFVAKVRVALQEAIASFTAINSYKDHPTDGSKLEVTYLDNQKHVLSTYSTYGITISQEIISESKPGYGTWNLLGAQTVTLDNQQTPTVFYHFERTA 1 1 1TJA A 1 334 P19062 1 334 1 334 1 1TJA B 1 334 P19062 1 334 1 334 2 1TJA C 1 288 P10927 1 288 1 288 2 1TJA D 1 288 P10927 1 288 1 288 2 1TJA E 1 288 P10927 1 288 1 288 3 1TJA F 1 219 P10929 1 219 1 219 3 1TJA G 1 219 P10929 1 219 1 219 3 1TJA H 1 219 P10929 1 219 1 219 P 6 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.00000 0.00000 0.00000 Three-dimensional rearrangement of proteins in the tail of bacteriophage t4 on infection of its host Cell (Cambridge,Mass.) 118 419 429 2004 CELLB5 US 0092-8674 0998 15315755 10.1016/j.cell.2004.07.022 polymer nat Baseplate structural protein Gp8 38070.215 2 polymer nat Baseplate structural protein Gp9 31031.002 3 polymer nat Baseplate structural protein Gp11 23735.793 3 polypeptide(L) no no MNDSSVIYRAIVTSKFRTEKMLNFYNSIGSGPDKNTIFITFGRSEPWSSNENEVGFAPPYPTDSVLGVTDMWTHMMGTVK VLPSMLDAVIPRRDWGDTRYPDPYTFRINDIVVCNSAPYNATESGAGWLVYRCLDVPDTGMCSIASLTDKDECLKLGGKW TPSARSMTPPEGRGDAEGTIEPGDGYVWEYLFEIPPDVSINRCTNEYIVVPWPEELKEDPTRWGYEDNLTWQQDDFGLIY RVKANTIRFKAYLDSVYFPEAALPGNKGFRQISIITNPLEAKAHPNDPNVKAEKDYYDPEDLMRHSGEMIYMENRPPIIM AMDQTEEINILFTF MNDSSVIYRAIVTSKFRTEKMLNFYNSIGSGPDKNTIFITFGRSEPWSSNENEVGFAPPYPTDSVLGVTDMWTHMMGTVK VLPSMLDAVIPRRDWGDTRYPDPYTFRINDIVVCNSAPYNATESGAGWLVYRCLDVPDTGMCSIASLTDKDECLKLGGKW TPSARSMTPPEGRGDAEGTIEPGDGYVWEYLFEIPPDVSINRCTNEYIVVPWPEELKEDPTRWGYEDNLTWQQDDFGLIY RVKANTIRFKAYLDSVYFPEAALPGNKGFRQISIITNPLEAKAHPNDPNVKAEKDYYDPEDLMRHSGEMIYMENRPPIIM AMDQTEEINILFTF polypeptide(L) no no MFIQEPKKLIDTGEIGNASTGDILFDGGNKINSDFNAIYNAFGDQRKMAVANGTGADGQIIHATGYYQKHSITEYATPVK VGTRHDIDTSTVGVKVIIERGELGDCVEFINSNGSISVTNPLTIQAIDSIKGVSGNLVVTSPYSKVTLRCISSDNSTSVW NYSIESMFGQKESPAEGTWNISTSGSVDIPLFHRTEYNMAKLLVTCQSVDGRKIKTAEINILVDTVNSEVISSEYAVMRV GNETEEDEIANIAFSIKENYVTATISSSTVGMRAAVKVIATQKIGVAQ MFIQEPKKLIDTGEIGNASTGDILFDGGNKINSDFNAIYNAFGDQRKMAVANGTGADGQIIHATGYYQKHSITEYATPVK VGTRHDIDTSTVGVKVIIERGELGDCVEFINSNGSISVTNPLTIQAIDSIKGVSGNLVVTSPYSKVTLRCISSDNSTSVW NYSIESMFGQKESPAEGTWNISTSGSVDIPLFHRTEYNMAKLLVTCQSVDGRKIKTAEINILVDTVNSEVISSEYAVMRV GNETEEDEIANIAFSIKENYVTATISSSTVGMRAAVKVIATQKIGVAQ polypeptide(L) no no MSLLNNKAGVISRLADFLGFRPKTGDIDVMNRQSVGSVTISQLAKGFYEPNIESAINDVHNFSIKDVGTIITNKTGVSPE GVSQTDYWAFSGTVTDDSLPPGSPITVLVFGLPVSATTGMTAIEFVAKVRVALQEAIASFTAINSYKDHPTDGSKLEVTY LDNQKHVLSTYSTYGITISQEIISESKPGYGTWNLLGAQTVTLDNQQTPTVFYHFERTA MSLLNNKAGVISRLADFLGFRPKTGDIDVMNRQSVGSVTISQLAKGFYEPNIESAINDVHNFSIKDVGTIITNKTGVSPE GVSQTDYWAFSGTVTDDSLPPGSPITVLVFGLPVSATTGMTAIEFVAKVRVALQEAIASFTAINSYKDHPTDGSKLEVTY LDNQKHVLSTYSTYGITISQEIISESKPGYGTWNLLGAQTVTLDNQQTPTVFYHFERTA virus Bacteriophage T4 D virus Bacteriophage T4 D virus Bacteriophage T4 D 1 1 A 2 2 A 3 3 A 4 4 A 5 5 A 6 6 A 7 7 7 ILE ILE A 8 8 8 TYR TYR A 9 9 9 ARG ARG A 10 10 10 ALA ALA A 11 11 11 ILE ILE A 12 12 12 VAL VAL A 13 13 13 THR THR A 14 14 14 SER SER A 15 15 15 LYS LYS A 16 16 16 PHE PHE A 17 17 17 ARG ARG A 18 18 18 THR THR A 19 19 19 GLU GLU A 20 20 20 LYS LYS A 21 21 21 MET MET A 22 22 22 LEU LEU A 23 23 23 ASN ASN A 24 24 24 PHE PHE A 25 25 25 TYR TYR A 26 26 26 ASN ASN A 27 27 27 SER SER A 28 28 28 ILE ILE A 29 29 29 GLY GLY A 30 30 30 SER SER A 31 31 31 GLY GLY A 32 32 32 PRO PRO A 33 33 33 ASP ASP A 34 34 34 LYS LYS A 35 35 35 ASN ASN A 36 36 36 THR THR A 37 37 37 ILE ILE A 38 38 38 PHE PHE A 39 39 39 ILE ILE A 40 40 40 THR THR A 41 41 41 PHE PHE A 42 42 42 GLY GLY A 43 43 43 ARG ARG A 44 44 44 SER SER A 45 45 45 GLU GLU A 46 46 46 PRO PRO A 47 47 47 TRP TRP A 48 48 48 SER SER A 49 49 49 SER SER A 50 50 50 ASN ASN A 51 51 51 GLU GLU A 52 52 52 ASN ASN A 53 53 53 GLU GLU A 54 54 54 VAL VAL A 55 55 55 GLY GLY A 56 56 56 PHE PHE A 57 57 57 ALA ALA A 58 58 58 PRO PRO A 59 59 59 PRO PRO A 60 60 60 TYR TYR A 61 61 61 PRO PRO A 62 62 62 THR THR A 63 63 63 ASP ASP A 64 64 64 SER SER A 65 65 65 VAL VAL A 66 66 66 LEU LEU A 67 67 67 GLY GLY A 68 68 68 VAL VAL A 69 69 69 THR THR A 70 70 70 ASP ASP A 71 71 71 MET MET A 72 72 72 TRP TRP A 73 73 73 THR THR A 74 74 74 HIS HIS A 75 75 75 MET MET A 76 76 76 MET MET A 77 77 77 GLY GLY A 78 78 78 THR THR A 79 79 79 VAL VAL A 80 80 80 LYS LYS A 81 81 81 VAL VAL A 82 82 82 LEU LEU A 83 83 83 PRO PRO A 84 84 84 SER SER A 85 85 85 MET MET A 86 86 86 LEU LEU A 87 87 87 ASP ASP A 88 88 88 ALA ALA A 89 89 89 VAL VAL A 90 90 90 ILE ILE A 91 91 91 PRO PRO A 92 92 92 ARG ARG A 93 93 93 ARG ARG A 94 94 94 ASP ASP A 95 95 95 TRP TRP A 96 96 96 GLY GLY A 97 97 97 ASP ASP A 98 98 98 THR THR A 99 99 99 ARG ARG A 100 100 100 TYR TYR A 101 101 101 PRO PRO A 102 102 102 ASP ASP A 103 103 103 PRO PRO A 104 104 104 TYR TYR A 105 105 105 THR THR A 106 106 106 PHE PHE A 107 107 107 ARG ARG A 108 108 108 ILE ILE A 109 109 109 ASN ASN A 110 110 110 ASP ASP A 111 111 111 ILE ILE A 112 112 112 VAL VAL A 113 113 113 VAL VAL A 114 114 114 CYS CYS A 115 115 115 ASN ASN A 116 116 116 SER SER A 117 117 117 ALA ALA A 118 118 118 PRO PRO A 119 119 119 TYR TYR A 120 120 120 ASN ASN A 121 121 121 ALA ALA A 122 122 122 THR THR A 123 123 123 GLU GLU A 124 124 124 SER SER A 125 125 125 GLY GLY A 126 126 126 ALA ALA A 127 127 127 GLY GLY A 128 128 128 TRP TRP A 129 129 129 LEU LEU A 130 130 130 VAL VAL A 131 131 131 TYR TYR A 132 132 132 ARG ARG A 133 133 133 CYS CYS A 134 134 134 LEU LEU A 135 135 135 ASP ASP A 136 136 136 VAL VAL A 137 137 137 PRO PRO A 138 138 138 ASP ASP A 139 139 139 THR THR A 140 140 140 GLY GLY A 141 141 141 MET MET A 142 142 142 CYS CYS A 143 143 143 SER SER A 144 144 144 ILE ILE A 145 145 145 ALA ALA A 146 146 146 SER SER A 147 147 147 LEU LEU A 148 148 148 THR THR A 149 149 149 ASP ASP A 150 150 150 LYS LYS A 151 151 151 ASP ASP A 152 152 152 GLU GLU A 153 153 153 CYS CYS A 154 154 154 LEU LEU A 155 155 155 LYS LYS A 156 156 156 LEU LEU A 157 157 157 GLY GLY A 158 158 158 GLY GLY A 159 159 159 LYS LYS A 160 160 160 TRP TRP A 161 161 161 THR THR A 162 162 162 PRO PRO A 163 163 163 SER SER A 164 164 164 ALA ALA A 165 165 165 ARG ARG A 166 166 166 SER SER A 167 167 167 MET MET A 168 168 168 THR THR A 169 169 169 PRO PRO A 170 170 170 PRO PRO A 171 171 171 GLU GLU A 172 172 172 GLY GLY A 173 173 173 ARG ARG A 174 174 174 GLY GLY A 175 175 175 ASP ASP A 176 176 176 ALA ALA A 177 177 177 GLU GLU A 178 178 178 GLY GLY A 179 179 179 THR THR A 180 180 180 ILE ILE A 181 181 181 GLU GLU A 182 182 182 PRO PRO A 183 183 183 GLY GLY A 184 184 184 ASP ASP A 185 185 185 GLY GLY A 186 186 186 TYR TYR A 187 187 187 VAL VAL A 188 188 188 TRP TRP A 189 189 189 GLU GLU A 190 190 190 TYR TYR A 191 191 191 LEU LEU A 192 192 192 PHE PHE A 193 193 193 GLU GLU A 194 194 194 ILE ILE A 195 195 195 PRO PRO A 196 196 196 PRO PRO A 197 197 197 ASP ASP A 198 198 198 VAL VAL A 199 199 199 SER SER A 200 200 200 ILE ILE A 201 201 201 ASN ASN A 202 202 202 ARG ARG A 203 203 203 CYS CYS A 204 204 204 THR THR A 205 205 205 ASN ASN A 206 206 206 GLU GLU A 207 207 207 TYR TYR A 208 208 208 ILE ILE A 209 209 209 VAL VAL A 210 210 210 VAL VAL A 211 211 211 PRO PRO A 212 212 212 TRP TRP A 213 213 213 PRO PRO A 214 214 214 GLU GLU A 215 215 215 GLU GLU A 216 216 216 LEU LEU A 217 217 217 LYS LYS A 218 218 218 GLU GLU A 219 219 219 ASP ASP A 220 220 220 PRO PRO A 221 221 221 THR THR A 222 222 222 ARG ARG A 223 223 223 TRP TRP A 224 224 224 GLY GLY A 225 225 225 TYR TYR A 226 226 226 GLU GLU A 227 227 227 ASP ASP A 228 228 228 ASN ASN A 229 229 229 LEU LEU A 230 230 230 THR THR A 231 231 231 TRP TRP A 232 232 232 GLN GLN A 233 233 233 GLN GLN A 234 234 234 ASP ASP A 235 235 235 ASP ASP A 236 236 236 PHE PHE A 237 237 237 GLY GLY A 238 238 238 LEU LEU A 239 239 239 ILE ILE A 240 240 240 TYR TYR A 241 241 241 ARG ARG A 242 242 242 VAL VAL A 243 243 243 LYS LYS A 244 244 244 ALA ALA A 245 245 245 ASN ASN A 246 246 246 THR THR A 247 247 247 ILE ILE A 248 248 248 ARG ARG A 249 249 249 PHE PHE A 250 250 250 LYS LYS A 251 251 251 ALA ALA A 252 252 252 TYR TYR A 253 253 253 LEU LEU A 254 254 254 ASP ASP A 255 255 255 SER SER A 256 256 256 VAL VAL A 257 257 257 TYR TYR A 258 258 258 PHE PHE A 259 259 259 PRO PRO A 260 260 260 GLU GLU A 261 261 261 ALA ALA A 262 262 262 ALA ALA A 263 263 263 LEU LEU A 264 264 264 PRO PRO A 265 265 265 GLY GLY A 266 266 266 ASN ASN A 267 267 267 LYS LYS A 268 268 268 GLY GLY A 269 269 269 PHE PHE A 270 270 270 ARG ARG A 271 271 271 GLN GLN A 272 272 272 ILE ILE A 273 273 273 SER SER A 274 274 274 ILE ILE A 275 275 275 ILE ILE A 276 276 276 THR THR A 277 277 277 ASN ASN A 278 278 278 PRO PRO A 279 279 279 LEU LEU A 280 280 280 GLU GLU A 281 281 281 ALA ALA A 282 282 282 LYS LYS A 283 283 283 ALA ALA A 284 284 284 HIS HIS A 285 285 285 PRO PRO A 286 286 286 ASN ASN A 287 287 287 ASP ASP A 288 288 288 PRO PRO A 289 289 289 ASN ASN A 290 290 290 VAL VAL A 291 291 291 LYS LYS A 292 292 292 ALA ALA A 293 293 293 GLU GLU A 294 294 294 LYS LYS A 295 295 295 ASP ASP A 296 296 296 TYR TYR A 297 297 297 TYR TYR A 298 298 298 ASP ASP A 299 299 299 PRO PRO A 300 300 300 GLU GLU A 301 301 301 ASP ASP A 302 302 302 LEU LEU A 303 303 303 MET MET A 304 304 304 ARG ARG A 305 305 305 HIS HIS A 306 306 306 SER SER A 307 307 307 GLY GLY A 308 308 308 GLU GLU A 309 309 309 MET MET A 310 310 310 ILE ILE A 311 311 311 TYR TYR A 312 312 312 MET MET A 313 313 313 GLU GLU A 314 314 314 ASN ASN A 315 315 315 ARG ARG A 316 316 316 PRO PRO A 317 317 317 PRO PRO A 318 318 318 ILE ILE A 319 319 319 ILE ILE A 320 320 320 MET MET A 321 321 321 ALA ALA A 322 322 322 MET MET A 323 323 323 ASP ASP A 324 324 324 GLN GLN A 325 325 325 THR THR A 326 326 326 GLU GLU A 327 327 327 GLU GLU A 328 328 328 ILE ILE A 329 329 329 ASN ASN A 330 330 330 ILE ILE A 331 331 331 LEU LEU A 332 332 332 PHE PHE A 333 333 333 THR THR A 334 334 334 PHE PHE A 1 1 B 2 2 B 3 3 B 4 4 B 5 5 B 6 6 B 7 7 7 ILE ILE B 8 8 8 TYR TYR B 9 9 9 ARG ARG B 10 10 10 ALA ALA B 11 11 11 ILE ILE B 12 12 12 VAL VAL B 13 13 13 THR THR B 14 14 14 SER SER B 15 15 15 LYS LYS B 16 16 16 PHE PHE B 17 17 17 ARG ARG B 18 18 18 THR THR B 19 19 19 GLU GLU B 20 20 20 LYS LYS B 21 21 21 MET MET B 22 22 22 LEU LEU B 23 23 23 ASN ASN B 24 24 24 PHE PHE B 25 25 25 TYR TYR B 26 26 26 ASN ASN B 27 27 27 SER SER B 28 28 28 ILE ILE B 29 29 29 GLY GLY B 30 30 30 SER SER B 31 31 31 GLY GLY B 32 32 32 PRO PRO B 33 33 33 ASP ASP B 34 34 34 LYS LYS B 35 35 35 ASN ASN B 36 36 36 THR THR B 37 37 37 ILE ILE B 38 38 38 PHE PHE B 39 39 39 ILE ILE B 40 40 40 THR THR B 41 41 41 PHE PHE B 42 42 42 GLY GLY B 43 43 43 ARG ARG B 44 44 44 SER SER B 45 45 45 GLU GLU B 46 46 46 PRO PRO B 47 47 47 TRP TRP B 48 48 48 SER SER B 49 49 49 SER SER B 50 50 50 ASN ASN B 51 51 51 GLU GLU B 52 52 52 ASN ASN B 53 53 53 GLU GLU B 54 54 54 VAL VAL B 55 55 55 GLY GLY B 56 56 56 PHE PHE B 57 57 57 ALA ALA B 58 58 58 PRO PRO B 59 59 59 PRO PRO B 60 60 60 TYR TYR B 61 61 61 PRO PRO B 62 62 62 THR THR B 63 63 63 ASP ASP B 64 64 64 SER SER B 65 65 65 VAL VAL B 66 66 66 LEU LEU B 67 67 67 GLY GLY B 68 68 68 VAL VAL B 69 69 69 THR THR B 70 70 70 ASP ASP B 71 71 71 MET MET B 72 72 72 TRP TRP B 73 73 73 THR THR B 74 74 74 HIS HIS B 75 75 75 MET MET B 76 76 76 MET MET B 77 77 77 GLY GLY B 78 78 78 THR THR B 79 79 79 VAL VAL B 80 80 80 LYS LYS B 81 81 81 VAL VAL B 82 82 82 LEU LEU B 83 83 83 PRO PRO B 84 84 84 SER SER B 85 85 85 MET MET B 86 86 86 LEU LEU B 87 87 87 ASP ASP B 88 88 88 ALA ALA B 89 89 89 VAL VAL B 90 90 90 ILE ILE B 91 91 91 PRO PRO B 92 92 92 ARG ARG B 93 93 93 ARG ARG B 94 94 94 ASP ASP B 95 95 95 TRP TRP B 96 96 96 GLY GLY B 97 97 97 ASP ASP B 98 98 98 THR THR B 99 99 99 ARG ARG B 100 100 100 TYR TYR B 101 101 101 PRO PRO B 102 102 102 ASP ASP B 103 103 103 PRO PRO B 104 104 104 TYR TYR B 105 105 105 THR THR B 106 106 106 PHE PHE B 107 107 107 ARG ARG B 108 108 108 ILE ILE B 109 109 109 ASN ASN B 110 110 110 ASP ASP B 111 111 111 ILE ILE B 112 112 112 VAL VAL B 113 113 113 VAL VAL B 114 114 114 CYS CYS B 115 115 115 ASN ASN B 116 116 116 SER SER B 117 117 117 ALA ALA B 118 118 118 PRO PRO B 119 119 119 TYR TYR B 120 120 120 ASN ASN B 121 121 121 ALA ALA B 122 122 122 THR THR B 123 123 123 GLU GLU B 124 124 124 SER SER B 125 125 125 GLY GLY B 126 126 126 ALA ALA B 127 127 127 GLY GLY B 128 128 128 TRP TRP B 129 129 129 LEU LEU B 130 130 130 VAL VAL B 131 131 131 TYR TYR B 132 132 132 ARG ARG B 133 133 133 CYS CYS B 134 134 134 LEU LEU B 135 135 135 ASP ASP B 136 136 136 VAL VAL B 137 137 137 PRO PRO B 138 138 138 ASP ASP B 139 139 139 THR THR B 140 140 140 GLY GLY B 141 141 141 MET MET B 142 142 142 CYS CYS B 143 143 143 SER SER B 144 144 144 ILE ILE B 145 145 145 ALA ALA B 146 146 146 SER SER B 147 147 147 LEU LEU B 148 148 148 THR THR B 149 149 149 ASP ASP B 150 150 150 LYS LYS B 151 151 151 ASP ASP B 152 152 152 GLU GLU B 153 153 153 CYS CYS B 154 154 154 LEU LEU B 155 155 155 LYS LYS B 156 156 156 LEU LEU B 157 157 157 GLY GLY B 158 158 158 GLY GLY B 159 159 159 LYS LYS B 160 160 160 TRP TRP B 161 161 161 THR THR B 162 162 162 PRO PRO B 163 163 163 SER SER B 164 164 164 ALA ALA B 165 165 165 ARG ARG B 166 166 166 SER SER B 167 167 167 MET MET B 168 168 168 THR THR B 169 169 169 PRO PRO B 170 170 170 PRO PRO B 171 171 171 GLU GLU B 172 172 172 GLY GLY B 173 173 173 ARG ARG B 174 174 174 GLY GLY B 175 175 175 ASP ASP B 176 176 176 ALA ALA B 177 177 177 GLU GLU B 178 178 178 GLY GLY B 179 179 179 THR THR B 180 180 180 ILE ILE B 181 181 181 GLU GLU B 182 182 182 PRO PRO B 183 183 183 GLY GLY B 184 184 184 ASP ASP B 185 185 185 GLY GLY B 186 186 186 TYR TYR B 187 187 187 VAL VAL B 188 188 188 TRP TRP B 189 189 189 GLU GLU B 190 190 190 TYR TYR B 191 191 191 LEU LEU B 192 192 192 PHE PHE B 193 193 193 GLU GLU B 194 194 194 ILE ILE B 195 195 195 PRO PRO B 196 196 196 PRO PRO B 197 197 197 ASP ASP B 198 198 198 VAL VAL B 199 199 199 SER SER B 200 200 200 ILE ILE B 201 201 201 ASN ASN B 202 202 202 ARG ARG B 203 203 203 CYS CYS B 204 204 204 THR THR B 205 205 205 ASN ASN B 206 206 206 GLU GLU B 207 207 207 TYR TYR B 208 208 208 ILE ILE B 209 209 209 VAL VAL B 210 210 210 VAL VAL B 211 211 211 PRO PRO B 212 212 212 TRP TRP B 213 213 213 PRO PRO B 214 214 214 GLU GLU B 215 215 215 GLU GLU B 216 216 216 LEU LEU B 217 217 217 LYS LYS B 218 218 218 GLU GLU B 219 219 219 ASP ASP B 220 220 220 PRO PRO B 221 221 221 THR THR B 222 222 222 ARG ARG B 223 223 223 TRP TRP B 224 224 224 GLY GLY B 225 225 225 TYR TYR B 226 226 226 GLU GLU B 227 227 227 ASP ASP B 228 228 228 ASN ASN B 229 229 229 LEU LEU B 230 230 230 THR THR B 231 231 231 TRP TRP B 232 232 232 GLN GLN B 233 233 233 GLN GLN B 234 234 234 ASP ASP B 235 235 235 ASP ASP B 236 236 236 PHE PHE B 237 237 237 GLY GLY B 238 238 238 LEU LEU B 239 239 239 ILE ILE B 240 240 240 TYR TYR B 241 241 241 ARG ARG B 242 242 242 VAL VAL B 243 243 243 LYS LYS B 244 244 244 ALA ALA B 245 245 245 ASN ASN B 246 246 246 THR THR B 247 247 247 ILE ILE B 248 248 248 ARG ARG B 249 249 249 PHE PHE B 250 250 250 LYS LYS B 251 251 251 ALA ALA B 252 252 252 TYR TYR B 253 253 253 LEU LEU B 254 254 254 ASP ASP B 255 255 255 SER SER B 256 256 256 VAL VAL B 257 257 257 TYR TYR B 258 258 258 PHE PHE B 259 259 259 PRO PRO B 260 260 260 GLU GLU B 261 261 261 ALA ALA B 262 262 262 ALA ALA B 263 263 263 LEU LEU B 264 264 264 PRO PRO B 265 265 265 GLY GLY B 266 266 266 ASN ASN B 267 267 267 LYS LYS B 268 268 268 GLY GLY B 269 269 269 PHE PHE B 270 270 270 ARG ARG B 271 271 271 GLN GLN B 272 272 272 ILE ILE B 273 273 273 SER SER B 274 274 274 ILE ILE B 275 275 275 ILE ILE B 276 276 276 THR THR B 277 277 277 ASN ASN B 278 278 278 PRO PRO B 279 279 279 LEU LEU B 280 280 280 GLU GLU B 281 281 281 ALA ALA B 282 282 282 LYS LYS B 283 283 283 ALA ALA B 284 284 284 HIS HIS B 285 285 285 PRO PRO B 286 286 286 ASN ASN B 287 287 287 ASP ASP B 288 288 288 PRO PRO B 289 289 289 ASN ASN B 290 290 290 VAL VAL B 291 291 291 LYS LYS B 292 292 292 ALA ALA B 293 293 293 GLU GLU B 294 294 294 LYS LYS B 295 295 295 ASP ASP B 296 296 296 TYR TYR B 297 297 297 TYR TYR B 298 298 298 ASP ASP B 299 299 299 PRO PRO B 300 300 300 GLU GLU B 301 301 301 ASP ASP B 302 302 302 LEU LEU B 303 303 303 MET MET B 304 304 304 ARG ARG B 305 305 305 HIS HIS B 306 306 306 SER SER B 307 307 307 GLY GLY B 308 308 308 GLU GLU B 309 309 309 MET MET B 310 310 310 ILE ILE B 311 311 311 TYR TYR B 312 312 312 MET MET B 313 313 313 GLU GLU B 314 314 314 ASN ASN B 315 315 315 ARG ARG B 316 316 316 PRO PRO B 317 317 317 PRO PRO B 318 318 318 ILE ILE B 319 319 319 ILE ILE B 320 320 320 MET MET B 321 321 321 ALA ALA B 322 322 322 MET MET B 323 323 323 ASP ASP B 324 324 324 GLN GLN B 325 325 325 THR THR B 326 326 326 GLU GLU B 327 327 327 GLU GLU B 328 328 328 ILE ILE B 329 329 329 ASN ASN B 330 330 330 ILE ILE B 331 331 331 LEU LEU B 332 332 332 PHE PHE B 333 333 333 THR THR B 334 334 334 PHE PHE B 1 1 1 MET MET C 2 2 2 PHE PHE C 3 3 3 ILE ILE C 4 4 4 GLN GLN C 5 5 5 GLU GLU C 6 6 6 PRO PRO C 7 7 7 LYS LYS C 8 8 8 LYS LYS C 9 9 9 LEU LEU C 10 10 10 ILE ILE C 11 11 11 ASP ASP C 12 12 12 THR THR C 13 13 13 GLY GLY C 14 14 14 GLU GLU C 15 15 15 ILE ILE C 16 16 16 GLY GLY C 17 17 17 ASN ASN C 18 18 18 ALA ALA C 19 19 19 SER SER C 20 20 20 THR THR C 21 21 21 GLY GLY C 22 22 22 ASP ASP C 23 23 23 ILE ILE C 24 24 24 LEU LEU C 25 25 25 PHE PHE C 26 26 26 ASP ASP C 27 27 27 GLY GLY C 28 28 28 GLY GLY C 29 29 29 ASN ASN C 30 30 30 LYS LYS C 31 31 31 ILE ILE C 32 32 32 ASN ASN C 33 33 33 SER SER C 34 34 34 ASP ASP C 35 35 35 PHE PHE C 36 36 36 ASN ASN C 37 37 37 ALA ALA C 38 38 38 ILE ILE C 39 39 39 TYR TYR C 40 40 40 ASN ASN C 41 41 41 ALA ALA C 42 42 42 PHE PHE C 43 43 43 GLY GLY C 44 44 44 ASP ASP C 45 45 45 GLN GLN C 46 46 46 ARG ARG C 47 47 47 LYS LYS C 48 48 48 MET MET C 49 49 49 ALA ALA C 50 50 50 VAL VAL C 51 51 51 ALA ALA C 52 52 52 ASN ASN C 53 53 53 GLY GLY C 54 54 54 THR THR C 55 55 55 GLY GLY C 56 56 56 ALA ALA C 57 57 57 ASP ASP C 58 58 58 GLY GLY C 59 59 59 GLN GLN C 60 60 60 ILE ILE C 61 61 61 ILE ILE C 62 62 62 HIS HIS C 63 63 63 ALA ALA C 64 64 64 THR THR C 65 65 65 GLY GLY C 66 66 66 TYR TYR C 67 67 67 TYR TYR C 68 68 68 GLN GLN C 69 69 69 LYS LYS C 70 70 70 HIS HIS C 71 71 71 SER SER C 72 72 72 ILE ILE C 73 73 73 THR THR C 74 74 74 GLU GLU C 75 75 75 TYR TYR C 76 76 76 ALA ALA C 77 77 77 THR THR C 78 78 78 PRO PRO C 79 79 79 VAL VAL C 80 80 80 LYS LYS C 81 81 81 VAL VAL C 82 82 82 GLY GLY C 83 83 83 THR THR C 84 84 84 ARG ARG C 85 85 85 HIS HIS C 86 86 86 ASP ASP C 87 87 87 ILE ILE C 88 88 88 ASP ASP C 89 89 89 THR THR C 90 90 90 SER SER C 91 91 91 THR THR C 92 92 92 VAL VAL C 93 93 93 GLY GLY C 94 94 94 VAL VAL C 95 95 95 LYS LYS C 96 96 96 VAL VAL C 97 97 97 ILE ILE C 98 98 98 ILE ILE C 99 99 99 GLU GLU C 100 100 100 ARG ARG C 101 101 101 GLY GLY C 102 102 102 GLU GLU C 103 103 103 LEU LEU C 104 104 104 GLY GLY C 105 105 105 ASP ASP C 106 106 106 CYS CYS C 107 107 107 VAL VAL C 108 108 108 GLU GLU C 109 109 109 PHE PHE C 110 110 110 ILE ILE C 111 111 111 ASN ASN C 112 112 112 SER SER C 113 113 113 ASN ASN C 114 114 114 GLY GLY C 115 115 115 SER SER C 116 116 116 ILE ILE C 117 117 117 SER SER C 118 118 118 VAL VAL C 119 119 119 THR THR C 120 120 120 ASN ASN C 121 121 121 PRO PRO C 122 122 122 LEU LEU C 123 123 123 THR THR C 124 124 124 ILE ILE C 125 125 125 GLN GLN C 126 126 126 ALA ALA C 127 127 127 ILE ILE C 128 128 128 ASP ASP C 129 129 129 SER SER C 130 130 130 ILE ILE C 131 131 131 LYS LYS C 132 132 132 GLY GLY C 133 133 133 VAL VAL C 134 134 134 SER SER C 135 135 135 GLY GLY C 136 136 136 ASN ASN C 137 137 137 LEU LEU C 138 138 138 VAL VAL C 139 139 139 VAL VAL C 140 140 140 THR THR C 141 141 141 SER SER C 142 142 142 PRO PRO C 143 143 143 TYR TYR C 144 144 144 SER SER C 145 145 145 LYS LYS C 146 146 146 VAL VAL C 147 147 147 THR THR C 148 148 148 LEU LEU C 149 149 149 ARG ARG C 150 150 150 CYS CYS C 151 151 151 ILE ILE C 152 152 152 SER SER C 153 153 153 SER SER C 154 154 154 ASP ASP C 155 155 155 ASN ASN C 156 156 156 SER SER C 157 157 157 THR THR C 158 158 158 SER SER C 159 159 159 VAL VAL C 160 160 160 TRP TRP C 161 161 161 ASN ASN C 162 162 162 TYR TYR C 163 163 163 SER SER C 164 164 164 ILE ILE C 165 165 165 GLU GLU C 166 166 166 SER SER C 167 167 167 MET MET C 168 168 168 PHE PHE C 169 169 169 GLY GLY C 170 170 170 GLN GLN C 171 171 171 LYS LYS C 172 172 172 GLU GLU C 173 173 173 SER SER C 174 174 174 PRO PRO C 175 175 175 ALA ALA C 176 176 176 GLU GLU C 177 177 177 GLY GLY C 178 178 178 THR THR C 179 179 179 TRP TRP C 180 180 180 ASN ASN C 181 181 181 ILE ILE C 182 182 182 SER SER C 183 183 183 THR THR C 184 184 184 SER SER C 185 185 185 GLY GLY C 186 186 186 SER SER C 187 187 187 VAL VAL C 188 188 188 ASP ASP C 189 189 189 ILE ILE C 190 190 190 PRO PRO C 191 191 191 LEU LEU C 192 192 192 PHE PHE C 193 193 193 HIS HIS C 194 194 194 ARG ARG C 195 195 195 THR THR C 196 196 196 GLU GLU C 197 197 197 TYR TYR C 198 198 198 ASN ASN C 199 199 199 MET MET C 200 200 200 ALA ALA C 201 201 201 LYS LYS C 202 202 202 LEU LEU C 203 203 203 LEU LEU C 204 204 204 VAL VAL C 205 205 205 THR THR C 206 206 206 CYS CYS C 207 207 207 GLN GLN C 208 208 208 SER SER C 209 209 209 VAL VAL C 210 210 210 ASP ASP C 211 211 211 GLY GLY C 212 212 212 ARG ARG C 213 213 213 LYS LYS C 214 214 214 ILE ILE C 215 215 215 LYS LYS C 216 216 216 THR THR C 217 217 217 ALA ALA C 218 218 218 GLU GLU C 219 219 219 ILE ILE C 220 220 220 ASN ASN C 221 221 221 ILE ILE C 222 222 222 LEU LEU C 223 223 223 VAL VAL C 224 224 224 ASP ASP C 225 225 225 THR THR C 226 226 226 VAL VAL C 227 227 227 ASN ASN C 228 228 228 SER SER C 229 229 229 GLU GLU C 230 230 230 VAL VAL C 231 231 231 ILE ILE C 232 232 232 SER SER C 233 233 233 SER SER C 234 234 234 GLU GLU C 235 235 235 TYR TYR C 236 236 236 ALA ALA C 237 237 237 VAL VAL C 238 238 238 MET MET C 239 239 239 ARG ARG C 240 240 240 VAL VAL C 241 241 241 GLY GLY C 242 242 242 ASN ASN C 243 243 243 GLU GLU C 244 244 244 THR THR C 245 245 245 GLU GLU C 246 246 246 GLU GLU C 247 247 247 ASP ASP C 248 248 248 GLU GLU C 249 249 249 ILE ILE C 250 250 250 ALA ALA C 251 251 251 ASN ASN C 252 252 252 ILE ILE C 253 253 253 ALA ALA C 254 254 254 PHE PHE C 255 255 255 SER SER C 256 256 256 ILE ILE C 257 257 257 LYS LYS C 258 258 258 GLU GLU C 259 259 259 ASN ASN C 260 260 260 TYR TYR C 261 261 261 VAL VAL C 262 262 262 THR THR C 263 263 263 ALA ALA C 264 264 264 THR THR C 265 265 265 ILE ILE C 266 266 266 SER SER C 267 267 267 SER SER C 268 268 268 SER SER C 269 269 269 THR THR C 270 270 270 VAL VAL C 271 271 271 GLY GLY C 272 272 272 MET MET C 273 273 273 ARG ARG C 274 274 274 ALA ALA C 275 275 275 ALA ALA C 276 276 276 VAL VAL C 277 277 277 LYS LYS C 278 278 278 VAL VAL C 279 279 279 ILE ILE C 280 280 280 ALA ALA C 281 281 281 THR THR C 282 282 282 GLN GLN C 283 283 283 LYS LYS C 284 284 284 ILE ILE C 285 285 285 GLY GLY C 286 286 286 VAL VAL C 287 287 287 ALA ALA C 288 288 288 GLN GLN C 1 1 1 MET MET D 2 2 2 PHE PHE D 3 3 3 ILE ILE D 4 4 4 GLN GLN D 5 5 5 GLU GLU D 6 6 6 PRO PRO D 7 7 7 LYS LYS D 8 8 8 LYS LYS D 9 9 9 LEU LEU D 10 10 10 ILE ILE D 11 11 11 ASP ASP D 12 12 12 THR THR D 13 13 13 GLY GLY D 14 14 14 GLU GLU D 15 15 15 ILE ILE D 16 16 16 GLY GLY D 17 17 17 ASN ASN D 18 18 18 ALA ALA D 19 19 19 SER SER D 20 20 20 THR THR D 21 21 21 GLY GLY D 22 22 22 ASP ASP D 23 23 23 ILE ILE D 24 24 24 LEU LEU D 25 25 25 PHE PHE D 26 26 26 ASP ASP D 27 27 27 GLY GLY D 28 28 28 GLY GLY D 29 29 29 ASN ASN D 30 30 30 LYS LYS D 31 31 31 ILE ILE D 32 32 32 ASN ASN D 33 33 33 SER SER D 34 34 34 ASP ASP D 35 35 35 PHE PHE D 36 36 36 ASN ASN D 37 37 37 ALA ALA D 38 38 38 ILE ILE D 39 39 39 TYR TYR D 40 40 40 ASN ASN D 41 41 41 ALA ALA D 42 42 42 PHE PHE D 43 43 43 GLY GLY D 44 44 44 ASP ASP D