1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.00000 0.00000 0.00000 2004-08-31 2004-06-03 1TJA 0 2004-10-05 1TJA 1 Situs v.2.0 REAL Laplacian filtered real space Situs v.2.0 1TJA Back projection 4.10442 3.93285 16 CTF correction of each particle Catalase crystals diffraction SINGLE PARTICLE bacteriophage T4 Phage treated with 3 M urea to contract tails H2O gene product 8 dimer gene product 9 trimer gene product 11 trimer 1 1 1 2002-01-06 100 FEI/PHILIPS CM300FEG/T 500 3400 0 0 1.4 BRIGHT FIELD 20 SPOT SCAN 45000 47000 FIELD EMISSION GUN 300 20 7.5 BACTERIA(EUBACTERIA) Escherichia coli Escherichia coli VIRION STRAIN 02.043.0.01.005 CRYO-ELECTRON MICROSCOPY REL N Y 2004-06-03 N N SR Y 2004-07-05 2004-06-03 2004-06-03 HPUB Y HOLD FOR PUBLICATION HOLD FOR PUBLICATION RELEASE NOW RCSB RCSB explicit Crystal structure of gp8 Crystal structure of gp9 Crystal structure of gp11 Fitting Of Gp8 Structure Into The Cryo-em Reconstruction Of The Bacteriophage T4 Baseplate Fitting Of Gp9 Structure Into The Cryo-em Reconstruction Of The Bacteriophage T4 Baseplate Fitting Of Gp11 Structure Into The Cryo-em Reconstruction Of The Bacteriophage T4 Baseplate MNDSSVIYRAIVTSKFRTEKMLNFYNSIGSGPDKNTIFITFGRSEPWSSNENEVGFAPPYPTDSVLGVTDMWTHMMGTVK VLPSMLDAVIPRRDWGDTRYPDPYTFRINDIVVCNSAPYNATESGAGWLVYRCLDVPDTGMCSIASLTDKDECLKLGGKW TPSARSMTPPEGRGDAEGTIEPGDGYVWEYLFEIPPDVSINRCTNEYIVVPWPEELKEDPTRWGYEDNLTWQQDDFGLIY RVKANTIRFKAYLDSVYFPEAALPGNKGFRQISIITNPLEAKAHPNDPNVKAEKDYYDPEDLMRHSGEMIYMENRPPIIM AMDQTEEINILFTF MFIQEPKKLIDTGEIGNASTGDILFDGGNKINSDFNAIYNAFGDQRKMAVANGTGADGQIIHATGYYQKHSITEYATPVK VGTRHDIDTSTVGVKVIIERGELGDCVEFINSNGSISVTNPLTIQAIDSIKGVSGNLVVTSPYSKVTLRCISSDNSTSVW NYSIESMFGQKESPAEGTWNISTSGSVDIPLFHRTEYNMAKLLVTCQSVDGRKIKTAEINILVDTVNSEVISSEYAVMRV GNETEEDEIANIAFSIKENYVTATISSSTVGMRAAVKVIATQKIGVAQ MSLLNNKAGVISRLADFLGFRPKTGDIDVMNRQSVGSVTISQLAKGFYEPNIESAINDVHNFSIKDVGTIITNKTGVSPE GVSQTDYWAFSGTVTDDSLPPGSPITVLVFGLPVSATTGMTAIEFVAKVRVALQEAIASFTAINSYKDHPTDGSKLEVTY LDNQKHVLSTYSTYGITISQEIISESKPGYGTWNLLGAQTVTLDNQQTPTVFYHFERTA VIRUS/VIRAL PROTEIN fitting, docking, cryo-EM, gp8, gp9, gp11 SWS VG08_BPT4 P19062 1 MNDSSVIYRAIVTSKFRTEKMLNFYNSIGSGPDKNTIFITFGRSEPWSSNENEVGFAPPYPTDSVLGVTDMWTHMMGTVKVLPSMLDAVIPRRDWGDTRYPDPYTFRINDIVVCNSAPYNATESGAGWLVYRCLDVPDTGMCSIASLTDKDECLKLGGKWTPSARSMTPPEGRGDAEGTIEPGDGYVWEYLFEIPPDVSINRCTNEYIVVPWPEELKEDPTRWGYEDNLTWQQDDFGLIYRVKANTIRFKAYLDSVYFPEAALPGNKGFRQISIITNPLEAKAHPNDPNVKAEKDYYDPEDLMRHSGEMIYMENRPPIIMAMDQTEEINILFTF 1 SWS VG09_BPT4 P10927 1 MFIQEPKKLIDTGEIGNASTGDILFDGGNKINSDFNAIYNAFGDQRKMAVANGTGADGQIIHATGYYQKHSITEYATPVKVGTRHDIDTSTVGVKVIIERGELGDCVEFINSNGSISVTNPLTIQAIDSIKGVSGNLVVTSPYSKVTLRCISSDNSTSVWNYSIESMFGQKESPAEGTWNISTSGSVDIPLFHRTEYNMAKLLVTCQSVDGRKIKTAEINILVDTVNSEVISSEYAVMRVGNETEEDEIANIAFSIKENYVTATISSSTVGMRAAVKVIATQKIGVAQ 1 SWS VG11_BPT4 P10929 2 MSLLNNKAGVISRLADFLGFRPKTGDIDVMNRQSVGSVTISQLAKGFYEPNIESAINDVHNFSIKDVGTIITNKTGVSPEGVSQTDYWAFSGTVTDDSLPPGSPITVLVFGLPVSATTGMTAIEFVAKVRVALQEAIASFTAINSYKDHPTDGSKLEVTYLDNQKHVLSTYSTYGITISQEIISESKPGYGTWNLLGAQTVTLDNQQTPTVFYHFERTA 1 1 1TJA A 1 334 P19062 1 334 1 334 1 1TJA B 1 334 P19062 1 334 1 334 2 1TJA C 1 288 P10927 1 288 1 288 2 1TJA D 1 288 P10927 1 288 1 288 2 1TJA E 1 288 P10927 1 288 1 288 3 1TJA F 1 219 P10929 1 219 1 219 3 1TJA G 1 219 P10929 1 219 1 219 3 1TJA H 1 219 P10929 1 219 1 219 P 6 1.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 1.000000 0.00000 0.00000 0.00000 Three-dimensional rearrangement of proteins in the tail of bacteriophage t4 on infection of its host Cell (Cambridge,Mass.) 118 419 429 2004 CELLB5 US 0092-8674 0998 15315755 polymer nat Baseplate structural protein Gp8 38070.215 2 polymer nat Baseplate structural protein Gp9 31031.002 3 polymer nat Baseplate structural protein Gp11 23735.793 3 polypeptide(L) no no MNDSSVIYRAIVTSKFRTEKMLNFYNSIGSGPDKNTIFITFGRSEPWSSNENEVGFAPPYPTDSVLGVTDMWTHMMGTVK VLPSMLDAVIPRRDWGDTRYPDPYTFRINDIVVCNSAPYNATESGAGWLVYRCLDVPDTGMCSIASLTDKDECLKLGGKW TPSARSMTPPEGRGDAEGTIEPGDGYVWEYLFEIPPDVSINRCTNEYIVVPWPEELKEDPTRWGYEDNLTWQQDDFGLIY RVKANTIRFKAYLDSVYFPEAALPGNKGFRQISIITNPLEAKAHPNDPNVKAEKDYYDPEDLMRHSGEMIYMENRPPIIM AMDQTEEINILFTF MNDSSVIYRAIVTSKFRTEKMLNFYNSIGSGPDKNTIFITFGRSEPWSSNENEVGFAPPYPTDSVLGVTDMWTHMMGTVK VLPSMLDAVIPRRDWGDTRYPDPYTFRINDIVVCNSAPYNATESGAGWLVYRCLDVPDTGMCSIASLTDKDECLKLGGKW TPSARSMTPPEGRGDAEGTIEPGDGYVWEYLFEIPPDVSINRCTNEYIVVPWPEELKEDPTRWGYEDNLTWQQDDFGLIY RVKANTIRFKAYLDSVYFPEAALPGNKGFRQISIITNPLEAKAHPNDPNVKAEKDYYDPEDLMRHSGEMIYMENRPPIIM AMDQTEEINILFTF polypeptide(L) no no MFIQEPKKLIDTGEIGNASTGDILFDGGNKINSDFNAIYNAFGDQRKMAVANGTGADGQIIHATGYYQKHSITEYATPVK VGTRHDIDTSTVGVKVIIERGELGDCVEFINSNGSISVTNPLTIQAIDSIKGVSGNLVVTSPYSKVTLRCISSDNSTSVW NYSIESMFGQKESPAEGTWNISTSGSVDIPLFHRTEYNMAKLLVTCQSVDGRKIKTAEINILVDTVNSEVISSEYAVMRV GNETEEDEIANIAFSIKENYVTATISSSTVGMRAAVKVIATQKIGVAQ MFIQEPKKLIDTGEIGNASTGDILFDGGNKINSDFNAIYNAFGDQRKMAVANGTGADGQIIHATGYYQKHSITEYATPVK VGTRHDIDTSTVGVKVIIERGELGDCVEFINSNGSISVTNPLTIQAIDSIKGVSGNLVVTSPYSKVTLRCISSDNSTSVW NYSIESMFGQKESPAEGTWNISTSGSVDIPLFHRTEYNMAKLLVTCQSVDGRKIKTAEINILVDTVNSEVISSEYAVMRV GNETEEDEIANIAFSIKENYVTATISSSTVGMRAAVKVIATQKIGVAQ polypeptide(L) no no MSLLNNKAGVISRLADFLGFRPKTGDIDVMNRQSVGSVTISQLAKGFYEPNIESAINDVHNFSIKDVGTIITNKTGVSPE GVSQTDYWAFSGTVTDDSLPPGSPITVLVFGLPVSATTGMTAIEFVAKVRVALQEAIASFTAINSYKDHPTDGSKLEVTY LDNQKHVLSTYSTYGITISQEIISESKPGYGTWNLLGAQTVTLDNQQTPTVFYHFERTA MSLLNNKAGVISRLADFLGFRPKTGDIDVMNRQSVGSVTISQLAKGFYEPNIESAINDVHNFSIKDVGTIITNKTGVSPE GVSQTDYWAFSGTVTDDSLPPGSPITVLVFGLPVSATTGMTAIEFVAKVRVALQEAIASFTAINSYKDHPTDGSKLEVTY LDNQKHVLSTYSTYGITISQEIISESKPGYGTWNLLGAQTVTLDNQQTPTVFYHFERTA virus Bacteriophage T4 D virus Bacteriophage T4 D virus Bacteriophage T4 D 1 1 A 2 2 A 3 3 A 4 4 A 5 5 A 6 6 A 7 7 7 ILE ILE A 8 8 8 TYR TYR A 9 9 9 ARG ARG A 10 10 10 ALA ALA A 11 11 11 ILE ILE A 12 12 12 VAL VAL A 13 13 13 THR THR A 14 14 14 SER SER A 15 15 15 LYS LYS A 16 16 16 PHE PHE A 17 17 17 ARG ARG A 18 18 18 THR THR A 19 19 19 GLU GLU A 20 20 20 LYS LYS A 21 21 21 MET MET A 22 22 22 LEU LEU A 23 23 23 ASN ASN A 24 24 24 PHE PHE A 25 25 25 TYR TYR A 26 26 26 ASN ASN A 27 27 27 SER SER A 28 28 28 ILE ILE A 29 29 29 GLY GLY A 30 30 30 SER SER A 31 31 31 GLY GLY A 32 32 32 PRO PRO A 33 33 33 ASP ASP A 34 34 34 LYS LYS A 35 35 35 ASN ASN A 36 36 36 THR THR A 37 37 37 ILE ILE A 38 38 38 PHE PHE A 39 39 39 ILE ILE A 40 40 40 THR THR A 41 41 41 PHE PHE A 42 42 42 GLY GLY A 43 43 43 ARG ARG A 44 44 44 SER SER A 45 45 45 GLU GLU A 46 46 46 PRO PRO A 47 47 47 TRP TRP A 48 48 48 SER SER A 49 49 49 SER SER A 50 50 50 ASN ASN A 51 51 51 GLU GLU A 52 52 52 ASN ASN A 53 53 53 GLU GLU A 54 54 54 VAL VAL A 55 55 55 GLY GLY A 56 56 56 PHE PHE A 57 57 57 ALA ALA A 58 58 58 PRO PRO A 59 59 59 PRO PRO A 60 60 60 TYR TYR A 61 61 61 PRO PRO A 62 62 62 THR THR A 63 63 63 ASP ASP A 64 64 64 SER SER A 65 65 65 VAL VAL A 66 66 66 LEU LEU A 67 67 67 GLY GLY A 68 68 68 VAL VAL A 69 69 69 THR THR A 70 70 70 ASP ASP A 71 71 71 MET MET A 72 72 72 TRP TRP A 73 73 73 THR THR A 74 74 74 HIS HIS A 75 75 75 MET MET A 76 76 76 MET MET A 77 77 77 GLY GLY A 78 78 78 THR THR A 79 79 79 VAL VAL A 80 80 80 LYS LYS A 81 81 81 VAL VAL A 82 82 82 LEU LEU A 83 83 83 PRO PRO A 84 84 84 SER SER A 85 85 85 MET MET A 86 86 86 LEU LEU A 87 87 87 ASP ASP A 88 88 88 ALA ALA A 89 89 89 VAL VAL A 90 90 90 ILE ILE A 91 91 91 PRO PRO A 92 92 92 ARG ARG A 93 93 93 ARG ARG A 94 94 94 ASP ASP A 95 95 95 TRP TRP A 96 96 96 GLY GLY A 97 97 97 ASP ASP A 98 98 98 THR THR A 99 99 99 ARG ARG A 100 100 100 TYR TYR A 101 101 101 PRO PRO A 102 102 102 ASP ASP A 103 103 103 PRO PRO A 104 104 104 TYR TYR A 105 105 105 THR THR A 106 106 106 PHE PHE A 107 107 107 ARG ARG A 108 108 108 ILE ILE A 109 109 109 ASN ASN A 110 110 110 ASP ASP A 111 111 111 ILE ILE A 112 112 112 VAL VAL A 113 113 113 VAL VAL A 114 114 114 CYS CYS A 115 115 115 ASN ASN A 116 116 116 SER SER A 117 117 117 ALA ALA A 118 118 118 PRO PRO A 119 119 119 TYR TYR A 120 120 120 ASN ASN A 121 121 121 ALA ALA A 122 122 122 THR THR A 123 123 123 GLU GLU A 124 124 124 SER SER A 125 125 125 GLY GLY A 126 126 126 ALA ALA A 127 127 127 GLY GLY A 128 128 128 TRP TRP A 129 129 129 LEU LEU A 130 130 130 VAL VAL A 131 131 131 TYR TYR A 132 132 132 ARG ARG A 133 133 133 CYS CYS A 134 134 134 LEU LEU A 135 135 135 ASP ASP A 136 136 136 VAL VAL A 137 137 137 PRO PRO A 138 138 138 ASP ASP A 139 139 139 THR THR A 140 140 140 GLY GLY A 141 141 141 MET MET A 142 142 142 CYS CYS A 143 143 143 SER SER A 144 144 144 ILE ILE A 145 145 145 ALA ALA A 146 146 146 SER SER A 147 147 147 LEU LEU A 148 148 148 THR THR A 149 149 149 ASP ASP A 150 150 150 LYS LYS A 151 151 151 ASP ASP A 152 152 152 GLU GLU A 153 153 153 CYS CYS A 154 154 154 LEU LEU A 155 155 155 LYS LYS A 156 156 156 LEU LEU A 157 157 157 GLY GLY A 158 158 158 GLY GLY A 159 159 159 LYS LYS A 160 160 160 TRP TRP A 161 161 161 THR THR A 162 162 162 PRO PRO A 163 163 163 SER SER A 164 164 164 ALA ALA A 165 165 165 ARG ARG A 166 166 166 SER SER A 167 167 167 MET MET A 168 168 168 THR THR A 169 169 169 PRO PRO A 170 170 170 PRO PRO A 171 171 171 GLU GLU A 172 172 172 GLY GLY A 173 173 173 ARG ARG A 174 174 174 GLY GLY A 175 175 175 ASP ASP A 176 176 176 ALA ALA A 177 177 177 GLU GLU A 178 178 178 GLY GLY A 179 179 179 THR THR A 180 180 180 ILE ILE A 181 181 181 GLU GLU A 182 182 182 PRO PRO A 183 183 183 GLY GLY A 184 184 184 ASP ASP A 185 185 185 GLY GLY A 186 186 186 TYR TYR A 187 187 187 VAL VAL A 188 188 188 TRP TRP A 189 189 189 GLU GLU A 190 190 190 TYR TYR A 191 191 191 LEU LEU A 192 192 192 PHE PHE A 193 193 193 GLU GLU A 194 194 194 ILE ILE A 195 195 195 PRO PRO A 196 196 196 PRO PRO A 197 197 197 ASP ASP A 198 198 198 VAL VAL A 199 199 199 SER SER A 200 200 200 ILE ILE A 201 201 201 ASN ASN A 202 202 202 ARG ARG A 203 203 203 CYS CYS A 204 204 204 THR THR A 205 205 205 ASN ASN A 206 206 206 GLU GLU A 207 207 207 TYR TYR A 208 208 208 ILE ILE A 209 209 209 VAL VAL A 210 210 210 VAL VAL A 211 211 211 PRO PRO A 212 212 212 TRP TRP A 213 213 213 PRO PRO A 214 214 214 GLU GLU A 215 215 215 GLU GLU A 216 216 216 LEU LEU A 217 217 217 LYS LYS A 218 218 218 GLU GLU A 219 219 219 ASP ASP A 220 220 220 PRO PRO A 221 221 221 THR THR A 222 222 222 ARG ARG A 223 223 223 TRP TRP A 224 224 224 GLY GLY A 225 225 225 TYR TYR A 226 226 226 GLU GLU A 227 227 227 ASP ASP A 228 228 228 ASN ASN A 229 229 229 LEU LEU A 230 230 230 THR THR A 231 231 231 TRP TRP A 232 232 232 GLN GLN A 233 233 233 GLN GLN A 234 234 234 ASP ASP A 235 235 235 ASP ASP A 236 236 236 PHE PHE A 237 237 237 GLY GLY A 238 238 238 LEU LEU A 239 239 239 ILE ILE A 240 240 240 TYR TYR A 241 241 241 ARG ARG A 242 242 242 VAL VAL A 243 243 243 LYS LYS A 244 244 244 ALA ALA A 245 245 245 ASN ASN A 246 246 246 THR THR A 247 247 247 ILE ILE A 248 248 248 ARG ARG A 249 249 249 PHE PHE A 250 250 250 LYS LYS A 251 251 251 ALA ALA A 252 252 252 TYR TYR A 253 253 253 LEU LEU A 254 254 254 ASP ASP A 255 255 255 SER SER A 256 256 256 VAL VAL A 257 257 257 TYR TYR A 258 258 258 PHE PHE A 259 259 259 PRO PRO A 260 260 260 GLU GLU A 261 261 261 ALA ALA A 262 262 262 ALA ALA A 263 263 263 LEU LEU A 264 264 264 PRO PRO A 265 265 265 GLY GLY A 266 266 266 ASN ASN A 267 267 267 LYS LYS A 268 268 268 GLY GLY A 269 269 269 PHE PHE A 270 270 270 ARG ARG A 271 271 271 GLN GLN A 272 272 272 ILE ILE A 273 273 273 SER SER A 274 274 274 ILE ILE A 275 275 275 ILE ILE A 276 276 276 THR THR A 277 277 277 ASN ASN A 278 278 278 PRO PRO A 279 279 279 LEU LEU A 280 280 280 GLU GLU A 281 281 281 ALA ALA A 282 282 282 LYS LYS A 283 283 283 ALA ALA A 284 284 284 HIS HIS A 285 285 285 PRO PRO A 286 286 286 ASN ASN A 287 287 287 ASP ASP A 288 288 288 PRO PRO A 289 289 289 ASN ASN A 290 290 290 VAL VAL A 291 291 291 LYS LYS A 292 292 292 ALA ALA A 293 293 293 GLU GLU A 294 294 294 LYS LYS A 295 295 295 ASP ASP A 296 296 296 TYR TYR A 297 297 297 TYR TYR A 298 298 298 ASP ASP A 299 299 299 PRO PRO A 300 300 300 GLU GLU A 301 301 301 ASP ASP A 302 302 302 LEU LEU A 303 303 303 MET MET A 304 304 304 ARG ARG A 305 305 305 HIS HIS A 306 306 306 SER SER A 307 307 307 GLY GLY A 308 308 308 GLU GLU A 309 309 309 MET MET A 310 310 310 ILE ILE A 311 311 311 TYR TYR A 312 312 312 MET MET A 313 313 313 GLU GLU A 314 314 314 ASN ASN A 315 315 315 ARG ARG A 316 316 316 PRO PRO A 317 317 317 PRO PRO A 318 318 318 ILE ILE A 319 319 319 ILE ILE A 320 320 320 MET MET A 321 321 321 ALA ALA A 322 322 322 MET MET A 323 323 323 ASP ASP A 324 324 324 GLN GLN A 325 325 325 THR THR A 326 326 326 GLU GLU A 327 327 327 GLU GLU A 328 328 328 ILE ILE A 329 329 329 ASN ASN A 330 330 330 ILE ILE A 331 331 331 LEU LEU A 332 332 332 PHE PHE A 333 333 333 THR THR A 334 334 334 PHE PHE A 1 1 B 2 2 B 3 3 B 4 4 B 5 5 B 6 6 B 7 7 7 ILE ILE B 8 8 8 TYR TYR B 9 9 9 ARG ARG B 10 10 10 ALA ALA B 11 11 11 ILE ILE B 12 12 12 VAL VAL B 13 13 13 THR THR B 14 14 14 SER SER B 15 15 15 LYS LYS B 16 16 16 PHE PHE B 17 17 17 ARG ARG B 18 18 18 THR THR B 19 19 19 GLU GLU B 20 20 20 LYS LYS B 21 21 21 MET MET B 22 22 22 LEU LEU B 23 23 23 ASN ASN B 24 24 24 PHE PHE B 25 25 25 TYR TYR B 26 26 26 ASN ASN B 27 27 27 SER SER B 28 28 28 ILE ILE B 29 29 29 GLY GLY B 30 30 30 SER SER B 31 31 31 GLY GLY B 32 32 32 PRO PRO B 33 33 33 ASP ASP B 34 34 34 LYS LYS B 35 35 35 ASN ASN B 36 36 36 THR THR B 37 37 37 ILE ILE B 38 38 38 PHE PHE B 39 39 39 ILE ILE B 40 40 40 THR THR B 41 41 41 PHE PHE B 42 42 42 GLY GLY B 43 43 43 ARG ARG B 44 44 44 SER SER B 45 45 45 GLU GLU B 46 46 46 PRO PRO B 47 47 47 TRP TRP B 48 48 48 SER SER B 49 49 49 SER SER B 50 50 50 ASN ASN B 51 51 51 GLU GLU B 52 52 52 ASN ASN B 53 53 53 GLU GLU B 54 54 54 VAL VAL B 55 55 55 GLY GLY B 56 56 56 PHE PHE B 57 57 57 ALA ALA B 58 58 58 PRO PRO B 59 59 59 PRO PRO B 60 60 60 TYR TYR B 61 61 61 PRO PRO B 62 62 62 THR THR B 63 63 63 ASP ASP B 64 64 64 SER SER B 65 65 65 VAL VAL B 66 66 66 LEU LEU B 67 67 67 GLY GLY B 68 68 68 VAL VAL B 69 69 69 THR THR B 70 70 70 ASP ASP B 71 71 71 MET MET B 72 72 72 TRP TRP B 73 73 73 THR THR B 74 74 74 HIS HIS B 75 75 75 MET MET B 76 76 76 MET MET B 77 77 77 GLY GLY B 78 78 78 THR THR B 79 79 79 VAL VAL B 80 80 80 LYS LYS B 81 81 81 VAL VAL B 82 82 82 LEU LEU B 83 83 83 PRO PRO B 84 84 84 SER SER B 85 85 85 MET MET B 86 86 86 LEU LEU B 87 87 87 ASP ASP B 88 88 88 ALA ALA B 89 89 89 VAL VAL B 90 90 90 ILE ILE B 91 91 91 PRO PRO B 92 92 92 ARG ARG B 93 93 93 ARG ARG B 94 94 94 ASP ASP B 95 95 95 TRP TRP B 96 96 96 GLY GLY B 97 97 97 ASP ASP B 98 98 98 THR THR B 99 99 99 ARG ARG B 100 100 100 TYR TYR B 101 101 101 PRO PRO B 102 102 102 ASP ASP B 103 103 103 PRO PRO B 104 104 104 TYR TYR B 105 105 105 THR THR B 106 106 106 PHE PHE B 107 107 107 ARG ARG B 108 108 108 ILE ILE B 109 109 109 ASN ASN B 110 110 110 ASP ASP B 111 111 111 ILE ILE B 112 112 112 VAL VAL B 113 113 113 VAL VAL B 114 114 114 CYS CYS B 115 115 115 ASN ASN B 116 116 116 SER SER B 117 117 117 ALA ALA B 118 118 118 PRO PRO B 119 119 119 TYR TYR B 120 120 120 ASN ASN B 121 121 121 ALA ALA B 122 122 122 THR THR B 123 123 123 GLU GLU B 124 124 124 SER SER B 125 125 125 GLY GLY B 126 126 126 ALA ALA B 127 127 127 GLY GLY B 128 128 128 TRP TRP B 129 129 129 LEU LEU B 130 130 130 VAL VAL B 131 131 131 TYR TYR B 132 132 132 ARG ARG B 133 133 133 CYS CYS B 134 134 134 LEU LEU B 135 135 135 ASP ASP B 136 136 136 VAL VAL B 137 137 137 PRO PRO B 138 138 138 ASP ASP B 139 139 139 THR THR B 140 140 140 GLY GLY B 141 141 141 MET MET B 142 142 142 CYS CYS B 143 143 143 SER SER B 144 144 144 ILE ILE B 145 145 145 ALA ALA B 146 146 146 SER SER B 147 147 147 LEU LEU B 148 148 148 THR THR B 149 149 149 ASP ASP B 150 150 150 LYS LYS B 151 151 151 ASP ASP B 152 152 152 GLU GLU B 153 153 153 CYS CYS B 154 154 154 LEU LEU B 155 155 155 LYS LYS B 156 156 156 LEU LEU B 157 157 157 GLY GLY B 158 158 158 GLY GLY B 159 159 159 LYS LYS B 160 160 160 TRP TRP B 161 161 161 THR THR B 162 162 162 PRO PRO B 163 163 163 SER SER B 164 164 164 ALA ALA B 165 165 165 ARG ARG B 166 166 166 SER SER B 167 167 167 MET MET B 168 168 168 THR THR B 169 169 169 PRO PRO B 170 170 170 PRO PRO B 171 171 171 GLU GLU B 172 172 172 GLY GLY B 173 173 173 ARG ARG B 174 174 174 GLY GLY B 175 175 175 ASP ASP B 176 176 176 ALA ALA B 177 177 177 GLU GLU B 178 178 178 GLY GLY B 179 179 179 THR THR B 180 180 180 ILE ILE B 181 181 181 GLU GLU B 182 182 182 PRO PRO B 183 183 183 GLY GLY B 184 184 184 ASP ASP B 185 185 185 GLY GLY B 186 186 186 TYR TYR B 187 187 187 VAL VAL B 188 188 188 TRP TRP B 189 189 189 GLU GLU B 190 190 190 TYR TYR B 191 191 191 LEU LEU B 192 192 192 PHE PHE B 193 193 193 GLU GLU B 194 194 194 ILE ILE B 195 195 195 PRO PRO B 196 196 196 PRO PRO B 197 197 197 ASP ASP B 198 198 198 VAL VAL B 199 199 199 SER SER B 200 200 200 ILE ILE B 201 201 201 ASN ASN B 202 202 202 ARG ARG B 203 203 203 CYS CYS B 204 204 204 THR THR B 205 205 205 ASN ASN B 206 206 206 GLU GLU B 207 207 207 TYR TYR B 208 208 208 ILE ILE B 209 209 209 VAL VAL B 210 210 210 VAL VAL B 211 211 211 PRO PRO B 212 212 212 TRP TRP B 213 213 213 PRO PRO B 214 214 214 GLU GLU B 215 215 215 GLU GLU B 216 216 216 LEU LEU B 217 217 217 LYS LYS B 218 218 218 GLU GLU B 219 219 219 ASP ASP B 220 220 220 PRO PRO B 221 221 221 THR THR B 222 222 222 ARG ARG B 223 223 223 TRP TRP B 224 224 224 GLY GLY B 225 225 225 TYR TYR B 226 226 226 GLU GLU B 227 227 227 ASP ASP B 228 228 228 ASN ASN B 229 229 229 LEU LEU B 230 230 230 THR THR B 231 231 231 TRP TRP B 232 232 232 GLN GLN B 233 233 233 GLN GLN B 234 234 234 ASP ASP B 235 235 235 ASP ASP B 236 236 236 PHE PHE B 237 237 237 GLY GLY B 238 238 238 LEU LEU B 239 239 239 ILE ILE B 240 240 240 TYR TYR B 241 241 241 ARG ARG B 242 242 242 VAL VAL B 243 243 243 LYS LYS B 244 244 244 ALA ALA B 245 245 245 ASN ASN B 246 246 246 THR THR B 247 247 247 ILE ILE B 248 248 248 ARG ARG B 249 249 249 PHE PHE B 250 250 250 LYS LYS B 251 251 251 ALA ALA B 252 252 252 TYR TYR B 253 253 253 LEU LEU B 254 254 254 ASP ASP B 255 255 255 SER SER B 256 256 256 VAL VAL B 257 257 257 TYR TYR B 258 258 258 PHE PHE B 259 259 259 PRO PRO B 260 260 260 GLU GLU B 261 261 261 ALA ALA B 262 262 262 ALA ALA B 263 263 263 LEU LEU B 264 264 264 PRO PRO B 265 265 265 GLY GLY B 266 266 266 ASN ASN B 267 267 267 LYS LYS B 268 268 268 GLY GLY B 269 269 269 PHE PHE B 270 270 270 ARG ARG B 271 271 271 GLN GLN B 272 272 272 ILE ILE B 273 273 273 SER SER B 274 274 274 ILE ILE B 275 275 275 ILE ILE B 276 276 276 THR THR B 277 277 277 ASN ASN B 278 278 278 PRO PRO B 279 279 279 LEU LEU B 280 280 280 GLU GLU B 281 281 281 ALA ALA B 282 282 282 LYS LYS B 283 283 283 ALA ALA B 284 284 284 HIS HIS B 285 285 285 PRO PRO B 286 286 286 ASN ASN B 287 287 287 ASP ASP B 288 288 288 PRO PRO B 289 289 289 ASN ASN B 290 290 290 VAL VAL B 291 291 291 LYS LYS B 292 292 292 ALA ALA B 293 293 293 GLU GLU B 294 294 294 LYS LYS B 295 295 295 ASP ASP B 296 296 296 TYR TYR B 297 297 297 TYR TYR B 298 298 298 ASP ASP B 299 299 299 PRO PRO B 300 300 300 GLU GLU B 301 301 301 ASP ASP B 302 302 302 LEU LEU B 303 303 303 MET MET B 304 304 304 ARG ARG B 305 305 305 HIS HIS B 306 306 306 SER SER B 307 307 307 GLY GLY B 308 308 308 GLU GLU B 309 309 309 MET MET B 310 310 310 ILE ILE B 311 311 311 TYR TYR B 312 312 312 MET MET B 313 313 313 GLU GLU B 314 314 314 ASN ASN B 315 315 315 ARG ARG B 316 316 316 PRO PRO B 317 317 317 PRO PRO B 318 318 318 ILE ILE B 319 319 319 ILE ILE B 320 320 320 MET MET B 321 321 321 ALA ALA B 322 322 322 MET MET B 323 323 323 ASP ASP B 324 324 324 GLN GLN B 325 325 325 THR THR B 326 326 326 GLU GLU B 327 327 327 GLU GLU B 328 328 328 ILE ILE B 329 329 329 ASN ASN B 330 330 330 ILE ILE B 331 331 331 LEU LEU B 332 332 332 PHE PHE B 333 333 333 THR THR B 334 334 334 PHE PHE B 1 1 1 MET MET C 2 2 2 PHE PHE C 3 3 3 ILE ILE C 4 4 4 GLN GLN C 5 5 5 GLU GLU C 6 6 6 PRO PRO C 7 7 7 LYS LYS C 8 8 8 LYS LYS C 9 9 9 LEU LEU C 10 10 10 ILE ILE C 11 11 11 ASP ASP C 12 12 12 THR THR C 13 13 13 GLY GLY C 14 14 14 GLU GLU C 15 15 15 ILE ILE C 16 16 16 GLY GLY C 17 17 17 ASN ASN C 18 18 18 ALA ALA C 19 19 19 SER SER C 20 20 20 THR THR C 21 21 21 GLY GLY C 22 22 22 ASP ASP C 23 23 23 ILE ILE C 24 24 24 LEU LEU C 25 25 25 PHE PHE C 26 26 26 ASP ASP C 27 27 27 GLY GLY C 28 28 28 GLY GLY C 29 29 29 ASN ASN C 30 30 30 LYS LYS C 31 31 31 ILE ILE C 32 32 32 ASN ASN C 33 33 33 SER SER C 34 34 34 ASP ASP C 35 35 35 PHE PHE C 36 36 36 ASN ASN C 37 37 37 ALA ALA C 38 38 38 ILE ILE C 39 39 39 TYR TYR C 40 40 40 ASN ASN C 41 41 41 ALA ALA C 42 42 42 PHE PHE C 43 43 43 GLY GLY C 44 44 44 ASP ASP C 45 45 45 GLN GLN C 46 46 46 ARG ARG C 47 47 47 LYS LYS C 48 48 48 MET MET C 49 49 49 ALA ALA C 50 50 50 VAL VAL C 51 51 51 ALA ALA C 52 52 52 ASN ASN C 53 53 53 GLY GLY C 54 54 54 THR THR C 55 55 55 GLY GLY C 56 56 56 ALA ALA C 57 57 57 ASP ASP C 58 58 58 GLY GLY C 59 59 59 GLN GLN C 60 60 60 ILE ILE C 61 61 61 ILE ILE C 62 62 62 HIS HIS C 63 63 63 ALA ALA C 64 64 64 THR THR C 65 65 65 GLY GLY C 66 66 66 TYR TYR C 67 67 67 TYR TYR C 68 68 68 GLN GLN C 69 69 69 LYS LYS C 70 70 70 HIS HIS C 71 71 71 SER SER C 72 72 72 ILE ILE C 73 73 73 THR THR C 74 74 74 GLU GLU C 75 75 75 TYR TYR C 76 76 76 ALA ALA C 77 77 77 THR THR C 78 78 78 PRO PRO C 79 79 79 VAL VAL C 80 80 80 LYS LYS C 81 81 81 VAL VAL C 82 82 82 GLY GLY C 83 83 83 THR THR C 84 84 84 ARG ARG C 85 85 85 HIS HIS C 86 86 86 ASP ASP C 87 87 87 ILE ILE C 88 88 88 ASP ASP C 89 89 89 THR THR C 90 90 90 SER SER C 91 91 91 THR THR C 92 92 92 VAL VAL C 93 93 93 GLY GLY C 94 94 94 VAL VAL C 95 95 95 LYS LYS C 96 96 96 VAL VAL C 97 97 97 ILE ILE C 98 98 98 ILE ILE C 99 99 99 GLU GLU C 100 100 100 ARG ARG C 101 101 101 GLY GLY C 102 102 102 GLU GLU C 103 103 103 LEU LEU C 104 104 104 GLY GLY C 105 105 105 ASP ASP C 106 106 106 CYS CYS C 107 107 107 VAL VAL C 108 108 108 GLU GLU C 109 109 109 PHE PHE C 110 110 110 ILE ILE C 111 111 111 ASN ASN C 112 112 112 SER SER C 113 113 113 ASN ASN C 114 114 114 GLY GLY C 115 115 115 SER SER C 116 116 116 ILE ILE C 117 117 117 SER SER C 118 118 118 VAL VAL C 119 119 119 THR THR C 120 120 120 ASN ASN C 121 121 121 PRO PRO C 122 122 122 LEU LEU C 123 123 123 THR THR C 124 124 124 ILE ILE C 125 125 125 GLN GLN C 126 126 126 ALA ALA C 127 127 127 ILE ILE C 128 128 128 ASP ASP C 129 129 129 SER SER C 130 130 130 ILE ILE C 131 131 131 LYS LYS C 132 132 132 GLY GLY C 133 133 133 VAL VAL C 134 134 134 SER SER C 135 135 135 GLY GLY C 136 136 136 ASN ASN C 137 137 137 LEU LEU C 138 138 138 VAL VAL C 139 139 139 VAL VAL C 140 140 140 THR THR C 141 141 141 SER SER C 142 142 142 PRO PRO C 143 143 143 TYR TYR C 144 144 144 SER SER C 145 145 145 LYS LYS C 146 146 146 VAL VAL C 147 147 147 THR THR C 148 148 148 LEU LEU C 149 149 149 ARG ARG C 150 150 150 CYS CYS C 151 151 151 ILE ILE C 152 152 152 SER SER C 153 153 153 SER SER C 154 154 154 ASP ASP C 155 155 155 ASN ASN C 156 156 156 SER SER C 157 157 157 THR THR C 158 158 158 SER SER C 159 159 159 VAL VAL C 160 160 160 TRP TRP C 161 161 161 ASN ASN C 162 162 162 TYR TYR C 163 163 163 SER SER C 164 164 164 ILE ILE C 165 165 165 GLU GLU C 166 166 166 SER SER C 167 167 167 MET MET C 168 168 168 PHE PHE C 169 169 169 GLY GLY C 170 170 170 GLN GLN C 171 171 171 LYS LYS C 172 172 172 GLU GLU C 173 173 173 SER SER C 174 174 174 PRO PRO C 175 175 175 ALA ALA C 176 176 176 GLU GLU C 177 177 177 GLY GLY C 178 178 178 THR THR C 179 179 179 TRP TRP C 180 180 180 ASN ASN C 181 181 181 ILE ILE C 182 182 182 SER SER C 183 183 183 THR THR C 184 184 184 SER SER C 185 185 185 GLY GLY C 186 186 186 SER SER C 187 187 187 VAL VAL C 188 188 188 ASP ASP C 189 189 189 ILE ILE C 190 190 190 PRO PRO C 191 191 191 LEU LEU C 192 192 192 PHE PHE C 193 193 193 HIS HIS C 194 194 194 ARG ARG C 195 195 195 THR THR C 196 196 196 GLU GLU C 197 197 197 TYR TYR C 198 198 198 ASN ASN C 199 199 199 MET MET C 200 200 200 ALA ALA C 201 201 201 LYS LYS C 202 202 202 LEU LEU C 203 203 203 LEU LEU C 204 204 204 VAL VAL C 205 205 205 THR THR C 206 206 206 CYS CYS C 207 207 207 GLN GLN C 208 208 208 SER SER C 209 209 209 VAL VAL C 210 210 210 ASP ASP C 211 211 211 GLY GLY C 212 212 212 ARG ARG C 213 213 213 LYS LYS C 214 214 214 ILE ILE C 215 215 215 LYS LYS C 216 216 216 THR THR C 217 217 217 ALA ALA C 218 218 218 GLU GLU C 219 219 219 ILE ILE C 220 220 220 ASN ASN C 221 221 221 ILE ILE C 222 222 222 LEU LEU C 223 223 223 VAL VAL C 224 224 224 ASP ASP C 225 225 225 THR THR C 226 226 226 VAL VAL C 227 227 227 ASN ASN C 228 228 228 SER SER C 229 229 229 GLU GLU C 230 230 230 VAL VAL C 231 231 231 ILE ILE C 232 232 232 SER SER C 233 233 233 SER SER C 234 234 234 GLU GLU C 235 235 235 TYR TYR C 236 236 236 ALA ALA C 237 237 237 VAL VAL C 238 238 238 MET MET C 239 239 239 ARG ARG C 240 240 240 VAL VAL C 241 241 241 GLY GLY C 242 242 242 ASN ASN C 243 243 243 GLU GLU C 244 244 244 THR THR C 245 245 245 GLU GLU C 246 246 246 GLU GLU C 247 247 247 ASP ASP C 248 248 248 GLU GLU C 249 249 249 ILE ILE C 250 250 250 ALA ALA C 251 251 251 ASN ASN C 252 252 252 ILE ILE C 253 253 253 ALA ALA C 254 254 254 PHE PHE C 255 255 255 SER SER C 256 256 256 ILE ILE C 257 257 257 LYS LYS C 258 258 258 GLU GLU C 259 259 259 ASN ASN C 260 260 260 TYR TYR C 261 261 261 VAL VAL C 262 262 262 THR THR C 263 263 263 ALA ALA C 264 264 264 THR THR C 265 265 265 ILE ILE C 266 266 266 SER SER C 267 267 267 SER SER C 268 268 268 SER SER C 269 269 269 THR THR C 270 270 270 VAL VAL C 271 271 271 GLY GLY C 272 272 272 MET MET C 273 273 273 ARG ARG C 274 274 274 ALA ALA C 275 275 275 ALA ALA C 276 276 276 VAL VAL C 277 277 277 LYS LYS C 278 278 278 VAL VAL C 279 279 279 ILE ILE C 280 280 280 ALA ALA C 281 281 281 THR THR C 282 282 282 GLN GLN C 283 283 283 LYS LYS C 284 284 284 ILE ILE C 285 285 285 GLY GLY C 286 286 286 VAL VAL C 287 287 287 ALA ALA C 288 288 288 GLN GLN C 1 1 1 MET MET D 2 2 2 PHE PHE D 3 3 3 ILE ILE D 4 4 4 GLN GLN D 5 5 5 GLU GLU D 6 6 6 PRO PRO D 7 7 7 LYS LYS D 8 8 8 LYS LYS D 9 9 9 LEU LEU D 10 10 10 ILE ILE D 11 11 11 ASP ASP D 12 12 12 THR THR D 13 13 13 GLY GLY D 14 14 14 GLU GLU D 15 15 15 ILE ILE D 16 16 16 GLY GLY D 17 17 17 ASN ASN D 18 18 18 ALA ALA D 19 19 19 SER SER D 20 20 20 THR THR D 21 21 21 GLY GLY D 22 22 22 ASP ASP D 23 23 23 ILE ILE D 24 24 24 LEU LEU D 25 25 25 PHE PHE D 26 26 26 ASP ASP D 27 27 27 GLY GLY D 28 28 28 GLY GLY D 29 29 29 ASN ASN D 30 30 30 LYS LYS D 31 31 31 ILE ILE D 32 32 32 ASN ASN D 33 33 33 SER SER D 34 34 34 ASP ASP D 35 35 35 PHE PHE D 36 36 36 ASN ASN D 37 37 37 ALA ALA D 38 38 38 ILE ILE D 39 39 39 TYR TYR D 40 40 40 ASN ASN D 41 41 41 ALA ALA D 42 42 42 PHE PHE D 43 43 43 GLY GLY D 44 44 44 ASP ASP D 45 45 45 GLN GLN D 46 46 46 ARG ARG D 47 47 47 <